ParkinsonCanadaV1, Main, Exploration, bibRecord, 002415

Bilateral impairments of skilled reach-to-eat in early Parkinson's disease patients presenting with unilateral or asymmetrical symptoms

Identifieur interne : 002415 ( Main/Exploration ); précédent : 002414; suivant : 002416

Bilateral impairments of skilled reach-to-eat in early Parkinson's disease patients presenting with unilateral or asymmetrical symptoms

Auteurs : Jon B. Doan [Canada] ; Kyle G. Melvin [Canada] ; Ian Q. Whishaw [Canada] ; Oksana Suchowersky [Canada]

Source :

Behavioural brain research [ 0166-4328 ] ; 2008.

RBID : Pascal:08-0456915

Descripteurs français

Pascal (Inist)
- Bilatéral, Habileté, Précoce, Maladie de Parkinson, Symptomatologie, Motricité, Mouvement orienté, Homme, Contrôle moteur.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Adult, Aged, Aged, 80 and over, Antiparkinson Agents (therapeutic use), Bilateral, Carbidopa (therapeutic use), Disability Evaluation, Double-Blind Method, Drug Combinations, Early, Feeding Behavior (drug effects), Feeding Behavior (physiology), Female, Follow-Up Studies, Functional Laterality (drug effects), Functional Laterality (physiology), Goal directed movement, Human, Humans, Levodopa (therapeutic use), Male, Middle Aged, Motor Skills Disorders (drug therapy), Motor Skills Disorders (etiology), Motor control, Motricity, Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson disease, Prospective Studies, Severity of Illness Index, Skill, Symptomatology.
MESH :
- chemical , therapeutic use : Antiparkinson Agents, Carbidopa, Levodopa.
- complications : Parkinson Disease.
- drug effects : Feeding Behavior, Functional Laterality.
- drug therapy : Motor Skills Disorders, Parkinson Disease.
- etiology : Motor Skills Disorders.
- physiology : Feeding Behavior, Functional Laterality.
- Adult, Aged, Aged, 80 and over, Disability Evaluation, Double-Blind Method, Drug Combinations, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prospective Studies, Severity of Illness Index.

Abstract

Previous studies have described limb and hand movement abnormalities in a reach-to-eat task in advanced Parkinson's disease (PD) and animal models of PD. The present study was directed toward examining reach-to-eat movements in early PD patients untreated with medication, along with a follow-up examination of a PD patient sub-group who were treated with a symptomatically stable dosage of dopamine replacement. Analysis of the reach-to-eat movement was made using blinded assessment under a validated scoring system, and comparisons were made on the total reach score and reach sub-component scores. In both examinations, PD patients had unilateral deficits or significant deficit asymmetry, as indicated by Unified Parkinson's Disease Rating Scale (UPDRS) scores. UPDRS motor scores were higher for the most-affected side of the body (mean scores of 10.45 and 4.25 for more- and less-affected upper limbs, respectively), whereas reach scores were equivalently impaired for the two sides (median scores of 12.35 and 12.56 for more- and less-affected limbs, respectively). These differences between clinical and experimental assessments of motor impairments persisted among early PD patients treated with medication. Thus, functional reaching shows bilateral and symmetrical abnormalities in early PD patients, even when clinical assessment shows asymmetrical or even unilateral impairment. These findings suggest that functional qualitative reaching evaluation is a sensitive test in early PD, and that significant bilateral abnormalities in reach function are present even in pre-clinical stages of the disease.

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">Previous studies have described limb and hand movement abnormalities in a reach-to-eat task in advanced Parkinson's disease (PD) and animal models of PD. The present study was directed toward examining reach-to-eat movements in early PD patients untreated with medication, along with a follow-up examination of a PD patient sub-group who were treated with a symptomatically stable dosage of dopamine replacement. Analysis of the reach-to-eat movement was made using blinded assessment under a validated scoring system, and comparisons were made on the total reach score and reach sub-component scores. In both examinations, PD patients had unilateral deficits or significant deficit asymmetry, as indicated by Unified Parkinson's Disease Rating Scale (UPDRS) scores. UPDRS motor scores were higher for the most-affected side of the body (mean scores of 10.45 and 4.25 for more- and less-affected upper limbs, respectively), whereas reach scores were equivalently impaired for the two sides (median scores of 12.35 and 12.56 for more- and less-affected limbs, respectively). These differences between clinical and experimental assessments of motor impairments persisted among early PD patients treated with medication. Thus, functional reaching shows bilateral and symmetrical abnormalities in early PD patients, even when clinical assessment shows asymmetrical or even unilateral impairment. These findings suggest that functional qualitative reaching evaluation is a sensitive test in early PD, and that significant bilateral abnormalities in reach function are present even in pre-clinical stages of the disease.</div>
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La maladie de Parkinson au Canada (serveur d'exploration)

Bilateral impairments of skilled reach-to-eat in early Parkinson's disease patients presenting with unilateral or asymmetrical symptoms

Bilateral impairments of skilled reach-to-eat in early Parkinson's disease patients presenting with unilateral or asymmetrical symptoms

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.